杰克(乔治·克鲁尼 George Clooney 饰)是一名劣迹斑斑又不太走运的江洋大盗,一次作案失败让他不得不面对为期三十年的牢狱之灾,心有不甘的杰克发誓绝不屈服于命运的安排,他决定越狱。 女警探凯伦(詹妮弗·洛佩兹 Jennifer Lopez 饰)出生于执法世家 ,可惜眼光不佳的她却总是栽在坏男人的手里,这不,一次偶然中,她遇见了正在越狱的杰克和伙伴巴迪(文·瑞姆斯 Ving Rhames 饰)并成为了两人的人质。在逃亡的途中,凯伦和杰克之间产生了感情,被迫分离后,亲手将爱人捉拿归案成为了凯伦唯一的理想。一个是运气不佳,一个是眼光不佳,这样两个倒霉蛋之间会擦出怎样的火花呢?A career bank robber busts out of jail (Clooney) with the help of his buddy (Rhames) and kidnaps a US Marshal (Lopez) in the process. When the two cons head for Detroit to pull off their final big scam, the Marshal is put on their case but she finds she is attracted to one of them and has second thoughts about bringing them in.