查小刀(孙俪 饰)智商极高,但性格软弱怕事,莫非里(邓超 饰)不过是一介混混,但个性嚣张跋扈,一场车祸让两人相遇,莫非里毫无意外的狠狠在查小刀的身上诈了一笔。亲情淡漠,工作受挫,又遭恶人欺压,查小刀心灰意冷,无意之中得知了有一位名为折耳根(梁超 饰)的神医专治各种疑难杂症,于是便起了向他寻求良方的念头。 让查小刀没有想到的是,莫非里居然也是折耳根的病人,常年的失眠困扰着他令他痛不欲生。折耳根告诉两人,他们其实正是彼此的“良药”,为了“治病”,查小刀和莫非里结为搭档共同进退,惹出了无数的麻烦和笑话,与此同时,亦结下了深厚的感情。An unscrupulous troublemaker suffering from erectile dysfunction has his world turned sideways, as an angel from above teaches him the consequences of sex and love, and why the two cannot be forced.