金波医生的妻子在家中被人谋杀,虽然金波当晚撞见独臂凶手并与之搏斗,但是凶手终于逃走,金波本人却因种种不利证据被判定为谋杀罪。在押解前往监狱的途中,一名犯人试图逃脱造成狱车事故,金波在混乱中搭救了一名警员并趁夜色逃逸。赶到事故现场的联邦司法官山姆接手此案追捕金波,山姆为人精明强干,作风强硬,更重要的是,他怀有一颗探求真相的正义之心。山姆带队与金波展开了节奏紧凑的追捕与反追捕,金波在四面无援的困境中,依靠为爱妻报仇的意念坚持了下来,并将山姆引向此案的真相。原来某大制药厂为使一种失败的新药通过审查,动用了篡改医疗报告等不法手段,不肯合作的金波于是成为了他们暗杀的对象……by:meijubar.netDr. Richard Kimble is accused as the murderer of his wife, tried and convicted. On his way to be executed, he escapes. The only chance to prove his innocence is to find the man who killed his wife. Kimble, pursued by Lt. Gerard, risks his life several times when he shows his identity to help other people out of trouble.